Keywords: Psychiatric Disorders, Psychiatric Disorders, Eating Disorder, MRS
Motivation: Anorexia nervosa (AN) is a mental and behavioral health condition. Less is known about eating-related anxiety and underlying neural mechanisms in AN.
Goal(s): We sought to characterize anxiety-to-eat in AN and examine the neurometabolic profile within the dACC using edited MRS.
Approach: Sixteen healthy women and 16 female AN patients were recruited. Edited MRS data were collected to measure 9 significant metabolites in the brain.
Results: Myo-inositol (mI) was lower in the dACC in AN relative to HC, and mI levels negatively predicted anxiety to eat high energy density foods only in the AN group.
Impact: Our findings provide new insight into the clinically challenging feature of eating-related anxiety in AN, and indicate mI levels in the dACC could serve as a novel biomarker of illness severity or potential therapeutic target in individuals vulnerable to AN.
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