Meeting Banner
Abstract #4102

Myo-inositol in the Dorsal Anterior Cingulate Cortex is Associated with Anxiety-to-Eat and independent of Body Weight in Anorexia Nervosa

Yulu Song1,2, Sarah H Guo3, Christopher W Davies-Jenkins1,2, Angela Guarda3, Richard A.E. Edden1,2, and Kimberly R Smith3
1Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Department of Psychiatry and Behavioral Science, Department of Psychiatry and Behavioral Science, Johns Hopkins School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Psychiatric Disorders, Psychiatric Disorders, Eating Disorder, MRS

Motivation: Anorexia nervosa (AN) is a mental and behavioral health condition. Less is known about eating-related anxiety and underlying neural mechanisms in AN.

Goal(s): We sought to characterize anxiety-to-eat in AN and examine the neurometabolic profile within the dACC using edited MRS.

Approach: Sixteen healthy women and 16 female AN patients were recruited. Edited MRS data were collected to measure 9 significant metabolites in the brain.

Results: Myo-inositol (mI) was lower in the dACC in AN relative to HC, and mI levels negatively predicted anxiety to eat high energy density foods only in the AN group.

Impact: Our findings provide new insight into the clinically challenging feature of eating-related anxiety in AN, and indicate mI levels in the dACC could serve as a novel biomarker of illness severity or potential therapeutic target in individuals vulnerable to AN.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords