Keywords: Psychiatric Disorders, Spectroscopy, Psychiatric Disorders
Motivation: Previous research using proton magnetic resonance spectroscopy (1H-MRS) has found neurotransmitter changes in neuropsychiatric disorders, notably in autism spectrum disorder (ASD); however, research on social skills interventions and metabolite changes is limited.
Goal(s): To explore how specific metabolite changes could reveal neurochemical roles in social learning in autistic youth.
Approach: We used ¹H-MRS to quantify neurotransmitter signals in the anterior cingulate cortex (ACC), a region underlying social cognition, to investigate the impact of a social skills intervention in autistic youth compared to neurotypical (NT) controls.
Results: Findings suggest that metabolite changes may reflect adaptive responses to social skills interventions in autistic youth.
Impact: This work connects behavioral and brain-based approaches in ASD treatment, helping identify markers of treatment response and improving the accuracy of interventions to enhance social outcomes for autistic youth.
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