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Abstract #4114

Diagnostic Value of Hybrid 18F-FDG and 18F-DPA-714 PET/MR in Refractory Epilepsy

Siqi Zhang1, Boyan Xu2, and Jie Lu1
1Department of Radiology and Nuclear Medicine, Xuanwu Hospital Capital Medical University, Beijing, China, 2GE Healthcare, MR Research, Beijing, China

Synopsis

Keywords: Epilepsy, Epilepsy

Motivation: Surgery is the only curative option for a third of refractory epilepsy patients, yet successful outcomes rely on the precise but challenging localization of the epileptogenic zone (EZ).

Goal(s): To assess EZ localization accuracy of hybrid 18F-DPA-714 and 18F-FDG PET/MR imaging in refractory epilepsy.

Approach: This retrospective study included 33 EZ resection patients, comparing preoperative 18F-DPA-714 and 18F-FDG PET/MR visual scores and asymmetry index with pathology using statistics.

Results: 18F-DPA-714 PET/MR had a higher visual score but a lower AI score than 18F-FDG (P < 0.01). The accuracies of localization with MRI, 18F-FDG and 18F-DPA-714 PET/MR were 63.6%(21/33), 84.8%(28/33), 78.8%(26/33).

Impact: Compared to MRI and 18F-FDG PET/MR, 18F-DPA-714 PET/MR offers clearer and more precise delineation of lesion borders while maintaining the high positive detection rate, thus providing valuable guidance for preoperative localization.

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