Keywords: Epilepsy, White Matter, Temporal Lobe Epilepsy; Hippocampal Sclerosis; Diffusion Tensor Imaging; Tract-based Spatial Statistics.
Motivation:Temporal lobe epilepsy (TLE) presents diagnostic challenges, particularly distinguishing between hippocampal sclerosis (HS) and TLE with normal MRI (TLE-NL).
Goal(s): This study aims to explore white matter changes in TLE subtypes to better understand their relationship and support clinical decision-making.
Approach:Forty-four TLE patients and 30 healthy controls underwent diffusion tensor imaging (DTI). Tract-based spatial statistics (TBSS) were used to analyze white matter microstructural changes.
Results:TLE patients showed decreased fractional anisotropy (FA) and increased mean diffusivity (MD) values, with HS patients exhibiting more extensive white matter damage than TLE-NL patients, suggesting they may be distinct diseases.
Impact: This study’s findings suggest that TLE-HS and TLE-NL are distinct diseases, potentially guiding more personalized treatment strategies and improving patient outcomes. Future research can further investigate the specific mechanisms underlying these differences to enhance diagnostic accuracy.
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