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Abstract #4120

Multiparametric characterization of hippocampal sclerosis using T1 and T2 normative modeling

Veronica Ravano1,2,3, Maria Eugenia Caligiuri4,5, Maria Celeste Bonacci4,5, Tommaso Di Noto1,2,3, Lina Bacha1,2,3, Gian Franco Piredda1, Jonathan A Disselhorst1,2,3, Domenico Zaca’6, Narly Golestani7, Alessandra Rampinini7, Irene Balboni7,8, Manuela Vaneckova9, Tobias Kober1,2,3, Tom Hilbert1,2,3, and Bénédicte Maréchal1,2,3
1Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland, 2LTS5, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 3Department of Medical Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, 4Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, Italy, 5Neuroscience Research Center, University Magna Graecia, Catanzaro, Italy, 6Siemens Healthcare srl, Milano, Italy, 7Department of Psychology, Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland, 8Institute of Multilingualism, University of Fribourg, Fribourg, Switzerland, 9Department of Radiology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

Synopsis

Keywords: Epilepsy, Relaxometry, quantitative imaging, normative modeling

Motivation: Multiparametric quantitative MRI allows the characterization of tissue microstructure and brain pathology. However, the combined estimation of regional T1 and T2 personalized deviations from a normative cohort remains underexplored.

Goal(s): To develop a novel normative model for regional T1, and T2 values and assess its clinical relevance in detecting microstructural abnormalities in epileptic patients with hippocampal sclerosis.

Approach: Normative models for T1, and T2 values were established and personalized regional deviations were extracted for individual patients. Brain asymmetry was assessed using the laterality index.

Results: Combined regional T1, and T2 personalized deviations showed potential in characterizing hippocampal sclerosis.

Impact: The study introduces a novel normative model for regional T1 and T2, enhancing the characterization of brain microstructure. This approach, assessed on epileptic patients with hippocampal sclerosis, highlights the clinical relevance of combined T1 and T2 mapping and laterality analysis.

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Abstract

Keywords