Abstract #4156

3D amplified MRI (aMRI) and Dynamic Mode Decomposition (DMD) analysis of ICP-driven cranio-spinal motion

Haribalan Kumar¹, Eryn Kwon^2,3, Jet Wright^2,3, Itamar Terem⁴, Alireza Sharifzadeh-Kermani³, Gonzalo Maso Talou³, Soroush Safaei², David Dubowitz^5,6, Miriam Scadeng^2,5, Taylor Emsden^2,5, Paul Condron^2,5, Leigh Potter², Daniel Cornfeld^2,5, Saralyn Mackenzie^2,7, Graham Wilson^2,7,8, David Freschini⁹, Joonsung Lee¹⁰, Matthew McDonald^2,11, Vickie Shim^2,3, Sarah-Jane Guild⁵, Helen Danesh-Meyer^2,12,13, Mehmet Kurt¹⁴, and Samantha Holdsworth^2,4

¹GE Healthcare, Auckland, New Zealand, ²Mātai Medical Research Institute, Tairāwhiti Gisborne, New Zealand, ³Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand, ⁴Department of Electrical Engineering, Stanford University, Stanford, CA, United States, ⁵Faculty of Medical and Health Sciences & Centre for Brain Research, University of Auckland, Auckland, New Zealand, ⁶Centre for Advanced MRI (CAMRI), University of Auckland, Auckland, New Zealand, ⁷Te Whatu Ora Tairāwhiti, Tairāwhiti Gisborne, New Zealand, ⁸Paediatrics and Child Health, University of Otago, Wellington, New Zealand, ⁹Chelsea Hospital, Tairāwhiti Gisborne, New Zealand, ¹⁰GE HealthCare, Seoul, Korea, Republic of, ¹¹Vision Research Foundation, Auckland, New Zealand, ¹²Department of Ophthalmology, University of Auckland, Auckland, New Zealand, ¹³Vision Research Foundation, University of Auckland, Auckland, New Zealand, ¹⁴Mechanical Engineering, University of Washington, Seattle, WA, United States

Synopsis

Keywords: Visualization, Neuro, Magnetic resonance imaging, Computer vision, Intracranial pulsatility

Motivation: Alterations in intracranial pressure (ICP) affect brain dynamics, with potential implications in idiopathic intracranial hypertension (IIH).

Goal(s): To develop a dynamical analysis method that can help visualize differences in intracranial and intraspinal pulsatility following lumbar puncture.

Approach: Dominant modal frequency and associated spatial patterns from dynamic mode decomposition were investigated based on amplified MR images of brain and spine, acquired pre- and post-lumbar puncture from IIH patients.

Results: Following lumbar puncture, shifts in dominant modes and spatial patterns of in the cranio-spinal region were observed, with a trend of increased spinal cord motion.

Impact: This study provides preliminary insights into how ICP change influenced cranio-spinal pulsatility. Spatiotemporal analysis methods have the potential to enhance patient care and support the continued development of advanced MRI techniques for clinical application.

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