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Abstract #4166

Assessment of Anthracycline-Induced Effects on Pericardial Adipose Tissue Using Magnetic Resonance Imaging: An Animal Study

Xing-yuan Kou1, Meng-xi Li2, Xiao-yong Zhang3, and Jing Chen2
1radiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China, 2radiology, The Affiliated Hospital of Southwest Medical University, luzhou,sichuan, China, 3Clinical Science, Philips Healthcare, Chengdu, China, Chengdu, sichuan, China

Synopsis

Keywords: Myocardium, Animals

Motivation: Anthracycline-induced cardiotoxicity (AIC) is a significant complication of chemotherapy, impacting both treatment and patient outcomes.

Goal(s): The study assessed PAT's diagnostic value by analyzing its changes in relation to other cardiac indices at various intervals.

Approach: This study evaluated pericardial adipose tissue (PAT) as a biomarker for AIC. Serial cardiac magnetic resonance imaging (MRI) was performed bi-weekly on chemotherapy-treated rabbits to monitor cardiac parameters.

Results: Results indicated that PAT alterations during chemotherapy could serve as a diagnostic tool for AIC, with established diagnostic thresholds.

Impact: Our experimental findings revealed changes in PAT during the chemotherapy cycle and validated its diagnostic efficacy, offering a new basis for cardiac injury detection and dose individualization of chemotherapeutic agents.

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Keywords