Keywords: Valves, Quantitative Imaging, Biomarkers, Data Analysis
Motivation: This study aims to introduce hemodynamic force (HDF) as a novel biomarker in assessing mitral regurgitation with preserved ejection fraction (MRpEF).
Goal(s): The fundamental goal of this study is to assess HDF non-invasively using 4D-flow MRI data to distinguish patients from healthy individuals and accurately identify mitral insufficiency associated with left-sided dysfunction.
Approach: This retrospective and cross-sectional study used 4D-flow MRI data to compute HDF as root mean square (RMS), average, and transverse-to-longitudinal ratio to evaluate its ability to detect MRpEF.
Results: Patients displayed distinct profiles from controls. Systolic (basal-apical) and diastolic (septal-lateral) RMS force emerged as crucial indicators of MR progression.
Impact: The integration of hemodynamic forces as a biomarker paves the way for innovative research opportunities, potentially revolutionizing non-invasive diagnostics. This study aims to enhance mitral regurgitation assessment, empowering clinicians for timely interventions and improved patient management.
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