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Abstract #4169

Physiological Pattern of Hemodynamic Forces in Mitral Patients with Normal Systolic Function: A Non-invasive Approach Through 4D-Flow MRI

Monisha Ghosh Srabanti1, Lyes Kadem2, and Julio Garcia3
1Biomedical Engineering, University of Calgary, Calgary, AB, Canada, 2Mechanical, Industrial, and Aero Engineering, Concordia University, Montreal, QC, Canada, 3Radiology, University of Calgary, Calgary, AB, Canada

Synopsis

Keywords: Valves, Quantitative Imaging, Biomarkers, Data Analysis

Motivation: This study aims to introduce hemodynamic force (HDF) as a novel biomarker in assessing mitral regurgitation with preserved ejection fraction (MRpEF).

Goal(s): The fundamental goal of this study is to assess HDF non-invasively using 4D-flow MRI data to distinguish patients from healthy individuals and accurately identify mitral insufficiency associated with left-sided dysfunction.

Approach: This retrospective and cross-sectional study used 4D-flow MRI data to compute HDF as root mean square (RMS), average, and transverse-to-longitudinal ratio to evaluate its ability to detect MRpEF.

Results: Patients displayed distinct profiles from controls. Systolic (basal-apical) and diastolic (septal-lateral) RMS force emerged as crucial indicators of MR progression.

Impact: The integration of hemodynamic forces as a biomarker paves the way for innovative research opportunities, potentially revolutionizing non-invasive diagnostics. This study aims to enhance mitral regurgitation assessment, empowering clinicians for timely interventions and improved patient management.

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