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Abstract #4172

Evaluation of anthracycline-induced cardiotoxicity using 1H-MRS compared with cardiac functional parameters: an animal study

Xing-yuan Kou1, Yu-lin Tu2, Xiao-yong Zhang3, and Jing Chen2
1radiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China, 2radiology, The Affiliated Hospital of Southwest Medical University, luzhou,sichuan, China, 3Clinical Science, Philips Healthcare, Chengdu, China, Chengdu, sichuan, China

Synopsis

Keywords: Myocardium, Animals

Motivation: The early detection of anthracycline-induced cardiotoxicity (AIC) is a significant challenge in chemotherapy, and timely identification is crucial for patients undergoing treatment.

Goal(s): This study aimed to assess the value of proton magnetic resonance spectroscopy (1H-MRS) in the early detection of AIC.

Approach: Rabbits were periodically administered chemotherapeutic drugs, magnetic resonance scans were conducted every two weeks to monitor changes in various cardiac parameters. 1H-MRS was compared with conventional cardiac parameters to determine the earliest detectable changes, diagnostic efficacy, and determination of diagnostic thresholds.

Results: The study revealed that Lipid1 changes early in the chemotherapy cycle and has good diagnostic efficacy.

Impact: This 1H-MRS study should offer an alternative for early identification of cardiac injury in patients with anthracycline-induced cardiotoxicity (AIC) and have potential for personalized dosing strategies of chemotherapeutic agents.

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