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Abstract #4177

Cardiac MR and biomechanical model-assisted framework for the assessment of healthy left ventricular energetics

Daniel F. Young1,2, Tarique Hussain2, and Maria Gusseva2
1Pediatric Cardiology, Heart Center - Research, Department of Pediatrics, Children's Medical Center Dallas, Dallas, TX, United States, 2Pediatric Cardiology, UT Southwesten Medical Center, Dallas, TX, United States

Synopsis

Keywords: Myocardium, Diagnosis/Prediction

Motivation: Establishing a baseline for cardiovascular energetics in healthy populations is crucial for comparing with disease states. However, the invasive nature of traditional pressure-volume (PV) assessments limits their applicability in healthy populations.

Goal(s): The aim was to assess healthy left ventricular (LV) energetics from noninvasively reconstructed PV loops using cardiovascular magnetic resonance (CMR) and arterial pressure data.

Approach: A biomechanical model provided patient-specific PV loops for 20 healthy LVs. Stroke work, ventricular elastance, and ventricular-arterial coupling were computed.

Results: LV functional metrics derived by the proposed noninvasive technique were consistent with those previously published using invasive PV loops.

Impact: The framework enables noninvasive PV loop assessment, providing a new tool for evaluating cardiac energetics in healthy individuals. This can improve our understanding of cardiovascular health and serve as a reference for identifying deviations in affected populations.

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