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Abstract #4188

An Interpretable Radiomics-based ML Model for Predicting Reverse Left Ventricular Remodeling in STEMI Patients Using LGE of Myocardial Scar

Xiuzheng Yue1,2, Jianing Cui3, Jing Qi1, Miao Hu1, Jianan Li1, Sicong Huang2, Tao Li4, and Kunlun He1
1Medical Innovation Research Department, Chinese PLA General Hospital, Beijing, China, 2Philips Healthcare, Beijing, China, 3Beijing Jishuitan Hospital, Capital Medical University, Beijing, China, 4Department of Radiology, the First Medical Center, Chinese PLA General Hospital, Beijing, China

Synopsis

Keywords: Myocardium, Heart, Ventricular Remodeling; Machine learning;

Motivation: Current imaging techniques face limitations in accurately predicting reverse left ventricular remodeling (r-LVR) in STEMI patients, an essential factor for guiding post-infarction treatment. This gap motivated us to explore advanced imaging and analysis methods to improve prediction accuracy.

Goal(s): This study aimed to improve r-LVR prediction by combining LGE-scar radiomics with conventional CMR markers in a LightGBM model.

Approach: We integrated radiomic features and CMR markers, using SHAP analysis to interpret the model’s predictions.

Results: The model achieved high accuracy (AUC: 0.890), surpassing traditional methods. SHAP analysis confirmed the interpretability of selected radiomic features, underscoring their clinical potential in supporting personalized treatment strategies.

Impact: This study advances r-LVR prediction in STEMI patients improving clinical outcomes. By combining radiomics with traditional CMR markers, it enables a deeper understanding of myocardial remodeling processes, potentially guiding future studies on cardiac tissue characterization and predictive modeling.

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