Keywords: Alzheimer's Disease, Relaxometry, T1ρ
Motivation: Alzheimer’s disease (AD) poses challenges in early diagnosis and intervention.
Goal(s): To explore novel MRI techniques for detecting early progression of AD.
Approach: Standard T1, adiabatic T1ρ and functional connectivity were measured in TGF344 rats and wild-type rats at 6-months and 12-months to evaluate brain microstructural and functional metrics over time.
Results: Significant group differences in T1ρ were observed in medial entorhinal and postrhinal cortices at 6-months, indicating early microstructural alterations. No group-differences were seen in T1 or at 12-months. Resting-state fMRI revealed different evolutions in connectivity over time across groups, suggesting functional reorganization associated with the disease.
Impact: These findings highlight the potential of adiabatic T1ρ and resting-state fMRI as valuable tools in evaluating Alzheimer’s disease progression, paving the way for future research focused on early diagnosis and intervention strategies.
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