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Abstract #4211

Age-related hippocampal connectivity alterations in HCP-Aging dataset

Huize Pang1,2, Chenyang Li1,2, Zhe Sun1,2, Zifei Liang1,2, Jiangyang Zhang1,2, and Yulin Ge1,2
1Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, 2Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States

Synopsis

Keywords: Aging, Aging, hippocampal tractography;

Motivation: While the hippocampus plays a key role in normal cognition and Alzheimer’s disease, studies examining diffusion characteristics along the tracts connecting the hippocampus with other brain regions in aging populations remain limited.

Goal(s): To map the major hippocampal connectivity pathways and investigate their age-related diffusion characteristics changes.

Approach: Leveraging high-resolution diffusion MRI from HCP-Aging, we mapped whole-brain white matter connections and isolated hippocampal sub-tracts, and analyzed hippocampal connections and diffusion parameters in relation to age.

Results: With aging, the density and streamline count of the global hippocampal connectivity were reduced, suggesting the degeneration of major hippocampal pathways.

Impact: These findings support the observed hippocampal volume changes in age-related cognitive decline, and provide insights into the 'hippocampal disconnection' theory, highlighting the importance of the integrity of hippocampal-centered white matter network associated with aging.

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