Keywords: Aging, Aging, Alzheimer’s Disease, Brain, Brain Connectivity, Data Analysis, Dementia, Neurodegeneration, fMRI (resting-state), fMRI Analysis, Functional Connectivity, White Matter
Motivation: White matter hyperintensity (WMH) burden is associated with vascular risk and impaired default mode network (DMN) function in aging. However, mechanisms underlying these relationships remain unclear.
Goal(s): Cerebrovascular reactivity (CVR), an indicator of vascular reserve, could provide mechanistic insight into how vascular injury in white matter affects functional connectivity (FC).
Approach: We leverage a novel CVR technique based on resting-state functional MRI to investigate how vascular injury (WMH) affects white matter cerebrovascular function and gray matter FC.
Results: Global WMH burden is negatively associated with relative CVR in the cingulum. Furthermore, cingulum relative CVR is positively associated with FC within the DMN.
Impact: This study provides mechanistic insight into how WMH burden affects cerebrovascular reactivity (measured by resting-state functional MRI) and functional connectivity in brain injury. This knowledge can help identify brain networks vulnerable to cerebrovascular injury and inform prevention of cognitive decline.
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