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Abstract #4217

Age-associated alterations of brain networks using dynamic ASL

Yakun Zhang1, Shichun Chen1, Zongpai Zhang1, Elizabeth Riley2, Adam K. Anderson2, Eve DeRosa2, and Weiying Dai1
1State University of New York at Binghamton, Binghamton, NY, United States, 2Cornell University, Ithaca, NY, United States

Synopsis

Keywords: Aging, Arterial spin labelling

Motivation: Motion may affect age-related discrepancy in resting-state functional connectivity (rsFC) in BOLD imaging studies. Dynamic arterial spin labeling (DASL) offers an alternative, detecting large-scale network rsFC with fewer motion artifacts. However, the aging effects on DASL rsFC remain unexplored.

Goal(s): We examined how brain networks evolve with age using DASL.

Approach: We used a data-driven approach to measure rsFC within and between brain networks in 131 adults.

Results: Older age correlated with reduced intra-network rsFC in the ventral stream (VSN), sensorimotor, left frontoparietal (LFPN), right frontoparietal, default mode (DMN), salience (SN), and frontal networks, and decreased inter-network rsFC between LFPN-SN, VSN-SN, and DMN-SN.

Impact: The rsFC of DASL may offer additional knowledge about the aging brain in the healthy adults and increase our insight into the neural basis of neurodegenerative disease.

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Keywords