Abstract #4219

Quantification of perforant path fiber degeneration using ex vivo 11.7T MRI along severities of neurofibrillary tangles in the entorhinal cortex

Yuto Uchida¹, Zhipeng Hou¹, Laura Gomez-Isaza², Maria Luongo², Juan C. Troncoso², Michael I. Miller³, Susumu Mori¹, and Kenichi Oishi^1,4,5

¹Radiology, Johns Hopkins University, Baltimore, MD, United States, ²Pathology, Johns Hopkins University, Baltimore, MD, United States, ³Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, ⁴Neurology, Johns Hopkins University, Baltimore, MD, United States, ⁵The Richman Family Precision Medicine Center of Excellence in Alzheimer’s Disease, Baltimore, MD, United States

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's Disease

Motivation: Degeneration of perforant path fibers is crucial in the process of Alzheimer’s disease (AD) pathogenesis as it is functionally related to memory deterioration.

Goal(s): This study aims to test whether the degeneration of perforant path fibers quantified by 11.7T MRI ex vivo is associated with neuropathological changes along the AD continuum.

Approach: Twenty postmortem brain tissues were scanned with 11.7T MRI for three-dimensional T2-weighted imaging, diffusion tensor imaging, and tractography, and were cut for subsequent histological examinations of AD pathology.

Results: Greater degeneration of perforant path fibers was observed in the group of higher severity of neurofibrillary tangles in the entorhinal cortex.

Impact: Myeloarchitectonic features of the perforant pathway, identified using 11.7 MRI in postmortem human brain tissues, were associated with neuropathological changes along the AD continuum, reflecting neurodegeneration of early AD pathogenesis.

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