Keywords: Alzheimer's Disease, Alzheimer's Disease
Motivation: Long-term occupational exposure to aluminum (Al) may contribute to mild cognitive impairment (MCI). However, the specific neural mechanism is still unclear.
Goal(s): Aimed to investigate the neurobiological mechanisms behind Al-induced MCI.
Approach: We collected clinical, cognitive scoring, and MRI data from workers with occupational Al exposure and normal individuals, comparing gray matter volume differences among groups and their correlation with cognition.
Results: There were differences in the volume of the bilateral caudate nucleus (CAU) among the three groups, with the smallest volume observed in patients with Al-induced MCI. The volume of the bilateral CAU was correlated with cognitive scores.
Impact: Occupational Al exposure may contribute to cognitive impairment, linked to bilateral CAU atrophy. Declines in memory function may further reduce cognitive ability by affecting CAU volume. Study offers insights into neural mechanisms underlying cognitive impairment related to occupational Al exposure.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords