Abstract #4229

Cerebrovascular Reactivity Modulates Spontaneous Brain Activity Abnormalities in Alzheimer's disease: A Resting-State Functional MRI Study

Xue Tang¹, Luoyu Wang^2,3, Qi Feng², Qingqing Wen⁴, Hanjun Hu^2,5, Yidi Zhu¹, Zhengluan Liao⁶, Zhongxiang Ding², and Xiufang Xu¹

¹School of Medical Imaging, Hangzhou Medical College, Hangzhou, China, ²Department of Radiology, Hangzhou First People’s Hospital, Hangzhou, China, ³School of Biomedical Engineering, Shanghai Tech University, Shanghai, China, ⁴MR Research, GE Healthcare, Beijing, China, ⁵The Fourth Clinical College, Zhejiang Chinese Medical University, Hangzhou, China, ⁶Department of Psychiatry, Zhejiang Provincial People’s Hospital/People’s Hospital of Hangzhou Medical College, Hangzhou, China

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's Disease, cerebrovascular reactivity

Motivation: In Alzheimer's disease (AD), the effect of vascular factors on the BOLD signal needs further study.

Goal(s): To investigate the alterations of the dynamic amplitude of low-frequency fluctuation (dALFF) following the adjustment of cerebrovascular reactivity (CVR) factors in AD patients.

Approach: A two-sample T-test with and without CVR as a covariate was conducted to assess the CVR’s impact on dALFF in 63 AD patients and 44 normal controls.

Results: Without CVR correction, there was no difference in brain regions in dALFF. After correction, dALFF of the left medial frontal gyrus (MFG) decreased in the AD group and was positively correlated with cognition function.

Impact: DALFF with CVR correction demonstrated enhanced sensitivity in detecting abnormal brain activity in AD patients and showed a significant correlation with cognition function, providing a new perspective for understanding the neurophysiological disruptions of AD.

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