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Abstract #4232

Increased iron deposition in the PCC of older women with aMCI

Tao Gong1 and Chenfei Ye2
1Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, 2International Research Institute for Artificial Intelligence, Harbin Institute of Technology at Shenzhen, Shenzhen, China

Synopsis

Keywords: Alzheimer's Disease, Quantitative Susceptibility mapping

Motivation: Understanding iron accumulation in neurodegenerative diseases, especially in early stages like aMCI, is crucial due to the lack of early biomarkers.

Goal(s): This study primarily aims to monitor changes in iron deposition across different brain regions using QSM, identify regions associated with cognitive function changes, and further investigate sex differences.

Approach: QSM based on strategically acquired gradient echo (STAGE) imaging was used to measure iron levels of aMCI patients and healthy controls, with cognitive assessments via MMSE and Memory_z.

Results: Significant PCC iron deposition in female aMCI patients correlated with cognitive decline before volume alterations, suggesting it as an early biomarker in women.

Impact: PCC iron deposition is a potential early biomarker for cognitive decline in aMCI before volume alterations, with sex-specific differences. This study suggests that gender should be considered in neurodegenerative research, paving the way for tailored diagnostic and therapeutic strategies.

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Keywords