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Abstract #4261

Two-Dimensional T1-T2 Encoded Pulse Sequence Development at 0.064T

Ella Wilczynski1, Nathan H. Williamson1,2, Alexandru V. Avram1, Francesco Padormo3, and Peter J. Basser1
1Section on Quantitative Imaging and Tissue Sciences (SQITS), National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD, United States, 2Military Traumatic Brain Injury Initiative (MTBI2), Henry M. Jackson Foundation (HJF) for the Advancement of Military Medicine, Bethesda, MD, United States, 3Hyperfine, Inc. Guilford, CT USA, Guilford, CT, United States

Synopsis

Keywords: Low-Field MRI, Low-Field MRI, Phantom, ultra-low field MRI

Motivation: Advancing the capabilities to characterize tissue microstructure on ultra-low field (ULF) MRI scanners enables large-scale longitudinal studies of brain developmental trajectories in normal and diseased pediatric populations.

Goal(s): To develop and vet new multi-dimensional MRI (mdMRI) sequences and processing pipelines for use in following brain developmental trajectories in pediatric subjects, which has never been demonstrated previously on ultralow-field MRI scanners.

Approach: We design, implement, and vet mdMRI pulse sequences on an ULF MRI scanner using quantitative diffusometry and relaxometry MRI phantoms.

Results: Good progress has been made migrating multi-dimensional MRI methods developed for high-field to ULF MRI scanners, which poses many challenges.

Impact: Little is known about healthy brain development of children in LMICs, where there is limited access to radiology. This project intends to improve our understanding of determinants of brain health and help democratize access to radiological resources worldwide.

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