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Abstract #4264

Enhanced Glioma Tumor Diagnostics with 3D printed Quality Assurance Phantom: GlioGuard

Gunnhild Ager-Wick1, Celine Skramstad2, Lars Ersland3, Morten Kristoffersen4, Rolf Arne Haakonsen4, Alexander Richard Craig-Craven5, and John Georg Seland6
1Chemistry, University of Bergen, Bergen, Norway, 2University of Bergen, Bergen, Norway, 3Department of Clinical Engineering, Haukeland University Hospital, Bergen, Norway, 4Medical Technology Department, Haukeland University Hospital, Bergen, Norway, 5Department of Biological and Medical Psychology, Haukeland University Hospital, Bergen, Norway, 6Department of Chemistry, University of Bergen, Bergen, Norway

Synopsis

Keywords: Phantoms, Spectroscopy, 2HG, phantom, brain tumor, glioma

Motivation: The GlioGuard phantom was developed to address the challenges in achieving accurate, reproducible 2HG measurements enabling optimization of MRS sequences and validation of basis sets for glioma diagnostics.

Goal(s): To evaluate GlioGuard’s capability of measuring 2HG concentrations accurately by comparing optimized MRS sequences; PRESS and sLASER.

Approach: GlioGuard used increasing 2HG concentrations in BRAINO solution, where the experiment was repeated with more Clariscan. MRS data from PRESS and sLASER sequences were acquired on a 3T scanner at Haukeland University Hospital. Data analysis involved metabolite quantification using Osprey [1].

Results: sLASER provided more reproducible measurements, suggesting higher robustness for 2HG detection in clinical QA.

Impact: GlioGuard standardizes 2HG detection in MRS, improving reliability and clinical relevance for glioma diagnostics. It provides cost-efficient, tumor-relevant compartments for accurate metabolite quantification, benefiting facilities without established MRS protocols or facilities focusing on optimization and quality assurance (QA).

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