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Abstract #4317

Association Between Epicardial Adipose Tissue, Left Atrial Strain and New-Onset Atrial Fibrillation in Patients with Hypertension Using CMR

Zhaoxia Yang1, Wenzhe Sun2, Dazong Tang3, and Liming Xia3
1Radiology, The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, China, 2Neurology, The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, China, 3Radiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Synopsis

Keywords: Arrhythmia, Hypertension, Left atrial strain; Atrial fibrillation; Epicardial adipose tissue; Mediation effect

Motivation: The study was designed to assess whether the LA strain had a potential mediation effect on the association between EAT and new-onset AF in hypertension.

Goal(s): To investigate the relationship between EAT thickness, LA strain, and new-onset AF in patients with essential hypertension and preserved LVEF.

Approach: 251 hypertensive patients were consecutively enrolled and CMR-derived quantitative parameters were assessed.

Results: Increased EAT thickness and decreased LA strain were independently associated with new-onset AF, with εs and εa might partially mediating the effect of thickened EAT on the increased risk of new-onset AF.

Impact: LA strain and EAT thickness parameters can sensitively detect LA dysfunction and epicardial fat deposition in hypertensive patients with new-onset AF, demonstrating great potential in prognosis of new-onset AF. Further study is needed to elucidate the underlying pathophysiological mechanisms.

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