Keywords: Arrhythmia, preclinical image analysis
Motivation: Atrial fibrillation (AF) is associated with left atrial remodeling, particularly through fibrosis.
Goal(s): To quantitatively analyze left atrial fibrosis distribution in AF patients and investigate differences between paroxysmal and persistent types of AF.
Approach: Using three-dimensional late gadolinium enhancement cardiac magnetic resonance, we assessed left atrial fibrosis distribution in AF patients. Multivariate analysis was performed to evaluate regional fibrosis as a risk factor for persistent AF.
Results: Fibrosis was concentrated in posterior wall and basal regions; fibrosis extent and severity were greater in persistent AF than in paroxysmal AF. Posterior wall fibrosis constituted a risk factor for persistent AF.
Impact: Three-dimensional late gadolinium enhancement cardiac magnetic resonance quantification of left atrial fibrosis distribution in AF patients provides insights into fibrosis patterns. Fibrosis in posterior wall zone 3 is a risk factor for persistent AF and potential target for personalized therapies.
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