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Abstract #4322

Quantitative analysis of left atrial fibrosis in atrial fibrillation patients using 3D Late Gadolinium-enhanced Cardiac MRI

Qifan Hua1, Zhiping Guo1, Yinghui Ge1, Jing An2, and Mengzhu Wang3
1Fuwai Central China Cardiovascular Hospital, Zhengzhou, China, 2Siemens Shenzhen Magnetic Resonance Ltd, Shenzhen, China, 3MR Research Collaboration, Siemens Healthineers Ltd, Bejing, China

Synopsis

Keywords: Arrhythmia, preclinical image analysis

Motivation: Atrial fibrillation (AF) is associated with left atrial remodeling, particularly through fibrosis.

Goal(s): To quantitatively analyze left atrial fibrosis distribution in AF patients and investigate differences between paroxysmal and persistent types of AF.

Approach: Using three-dimensional late gadolinium enhancement cardiac magnetic resonance, we assessed left atrial fibrosis distribution in AF patients. Multivariate analysis was performed to evaluate regional fibrosis as a risk factor for persistent AF.

Results: Fibrosis was concentrated in posterior wall and basal regions; fibrosis extent and severity were greater in persistent AF than in paroxysmal AF. Posterior wall fibrosis constituted a risk factor for persistent AF.

Impact: Three-dimensional late gadolinium enhancement cardiac magnetic resonance quantification of left atrial fibrosis distribution in AF patients provides insights into fibrosis patterns. Fibrosis in posterior wall zone 3 is a risk factor for persistent AF and potential target for personalized therapies.

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