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Abstract #4336

Towards whole-heart quantitative myocardial perfusion using dual-saturation and multiband acceleration

Giulio Ferrazzi1, Carlos Galan-Arriola2,3, Carlos Velasco Jimeno4, Carlos Real2,5, Matteo Ghidara1, Gonzalo López-Martín2, Borja Ibañez2,3,6, and Javier Sánchez González4
1Philips Healthcare, Milan, Italy, 2Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain, 3CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain, 4Philips Healthcare, Madrid, Spain, 5Department of Cardiology, Hospital Universitario Clínico San Carlos, Madrid, Spain, 6Cardiology Department, IIS-Fundación Jiménez Díaz University Hospital, Madrid, Spain

Synopsis

Keywords: Myocardium, Perfusion, Acquisition\Reconstruction Methods, Sedated Pigs, Dual Saturation, Multiband Imaging, Quantitative Perfusion

Motivation: Quantitative myocardial perfusion is limited to capturing 3 slices per heartbeat. This limitation highlights the need to increase the number of slices, aiming for full left ventricular coverage with absolute myocardial blood flow quantification.

Goal(s): To integrate quantitative perfusion imaging with simultaneous multi-slice (or multiband) excitation.

Approach: Multiband was integrated into an existing dual-saturation perfusion sequence. In-vivo experiments in healthy sedated pigs were conducted to evaluate the reliability of the technique under rest conditions.

Results: Combining dual-saturation sequences with multiband is feasible. The number of slices acquired with multiband was duplicated relative to gold standard. Myocardial Blood flow values were comparable and reproducible.

Impact: Combining quantitative perfusion imaging with multiband techniques expands myocardial coverage while ensuring precise blood flow quantitative measurements. This integration represents a significant advancement in potentially enhancing diagnostic capabilities in cardiovascular imaging.

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