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Abstract #4341

Imaging Delayed Phase Ferumoxytol-Enhancement with Cardiac QSM: a Pilot Animal Study in Acute Myocardial Infarction

Yuheng Huang1,2, Li-Ting Huang3, xingmin Guan1, Archana Malagi3, Chia-chi Yang3, Janet Wei4, Noel Bairey Merz4, Mohammad Ahmed ZakiAl-Ani5, Ellen Keeley5, Xiaoming Bi6, Yibin Xie3, Anthony Christodoulou7, Paul Finn7, Kim-Lien Nguyen7, Debiao Li3, Rohan Dharmakumar1, and Hsin-Jung Yang3
1krannert cardiovascular research center, Indiana University School of Medicine, Indianapolis, IN, United States, 2Bioengineering, UCLA, LA, CA, United States, 3Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, LA, CA, United States, 4Cardiology, Cedars-Sinai Medical Center, LA, CA, United States, 5Cardiology, University of Florida, Gainesville, FL, United States, 6Siemens Healthineers, LA, LA, United States, 7David Geffen School of Medicine, UCLA, LA, CA, United States

Synopsis

Keywords: Myocardium, Inflammation, Quantitative Susceptibility Mapping (QSM); Ferumoxytol;

Motivation: Delayed enhancement of Ferumoxytol has been associated with tissue inflammation in different organs, such as the brain and vessel walls. But its application to the myocardium has been restricted due to various technical challenges of conventional cardiac iron-sensitive (T2*) imaging.

Goal(s): This pilot study employs a confounder-mitigated cardiac QSM technique for precise myocardial iron quantification without the T2* confounders.

Approach: We tested the technique in pigs with acute myocardial infarction.

Results: Delayed-phase ferumoxytol-enhanced HDR-QSM shows reliable detection of elevated iron content in the edematous myocardium. Showing the potential for visualization and quantification of macrophage infiltration in myocardium post-acute myocardial infarction.

Impact: This pilot study demonstrates HDR-QSM’s potential for assessing myocardial inflammation, providing a promising tool to monitor post-MI healing and inform targeted therapeutic interventions. FDG PET imaging will be conducted in future studies to validate our findings

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Keywords