Meeting Banner
Abstract #4346

Structural and Metabolic Insights in Hypertrophic Cardiomyopathy Using LGE and Hyperpolarized 13C Magnetic Resonance Imaging

Avantika Sinha1, Xiaoxi Liu1, Shuyu Tang2, Nicholas Dwok3, Sanjay Sivalokanathan4, Jing Liu1, Robert Bok1, Yoo Jin Hong5, Karen G Ordovas6, Anna Bennett Haller1, Jim Slater1, Jeremy W Gordon1, Roselle M Abraham1, and Peder Larson1
1UCSF, San Francisco, CA, United States, 2Vista.ai, San Francisco, CA, United States, 3University of Colorado, Aurora, CO, United States, 4University of Pennsylvania, Philadelphia, PA, United States, 5Yonsei University, Seoul, Korea, Republic of, 6University of Washington, Seattle, WA, United States

Synopsis

Keywords: Myocardium, Heart, HCM, pyruvate, LVEF%

Motivation: Recent studies suggest that HCM may be fundamentally a metabolic disease.

Goal(s): We sought to explore any correlations between metabolism and late gadolinium enhancement in the myocardium that may provide further information on the various metabolic phenotypes of HCM.

Approach: We used hyperpolarized 13C-pyruvate MRI to quantify myocardial glycolytic and TCA metabolism and compared this to late gadolinium enhancement (LGE%) from clinical CMR.

Results: The findings support the hypothesis that HCM has a significant metabolic component and suggest that HP 13C-MRI could become a valuable tool for characterizing metabolic phenotypes in HCM, potentially aiding in diagnosis, prognosis, and treatment monitoring.

Impact: Standard-of-care cardiac magnetic resonance (CMR) provides information on physical form and function, but it does not offer metabolic information on tissue and such information from hyperpolarized 13C MRI could aid in diagnosis and translation of metabolic therapies.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords