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Abstract #4351

Evaluation of Tissue Characteristics Using Magnetic Resonance Fingerprinting in Dementia Patients with Various Clinical Stages

Chen-Wen Fang1, Xue-Zhe Lu2, Hung-Jen Hsieh3, Chi-Ju Lu3, and Ju-Min Wang3
1Department of Neurology, National Taiwan University Hospital, Yunlin Branch, Yunlin, Taiwan, 2Siemens Healthineers, Taipei, Taiwan, 3Department of Medical Imaging, National Taiwan University Hospital, Yunlin Branch, Yunlin, Taiwan

Synopsis

Keywords: Dementia, MR Fingerprinting, Dementia, Alzheimer

Motivation: The development of magnetic resonance fingerprinting (MRF) brought new insight of quantitative imaging but rare in neurodegenerative disease.

Goal(s): Investigate the change of tissue characteristics in certain regions of clinical dementia brain and explore the potential of MRF as an imaging biomarker.

Approach: We employed MRF in patients with symptoms of dementia, accompanied with clinical rating methods and diagnosis to study if tissue characteristics play a role in dementia patients.

Results: The T1 values of thalamus were different between types of dementia and clinical rating. The T1 values of putamen presents the correlation with clinical mental rating.

Impact: The potential of Magnetic resonance fingerprinting as a biomarker in patients with dementia was revealed. The changes of tissue characteristics in thalamus and putamen play a role in clinical dementia symptoms.

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