Keywords: Dementia, Alzheimer's Disease
Motivation: In Alzheimer’s disease , the hippocampus undergoes dynamic changes in volume and structure, paralleling similar changes observed post whole brain radiotherapy（WBRT）.
Goal(s): Multisequence magnetic resonance imaging (MRI) radiomic features were used to analyze dynamic changes in the hippocampus after radiotherapy.
Approach: Seventy-five patients were enrolled, and multi-sequence MRI radiomics—including T1WI, CE-T1WI, T2WI, T2 FLAIR, and DWI—assessed hippocampal alterations pre- and post-WBRT. Radiomic features, analyzed with RT-Mind software, were grouped into two categories based on MRI stage differences.
Results: Findings showed specific features from T1WI, CE-T1WI, and T2WI reflect microscopic changes, underscoring radiomics as a valuable tool for monitoring hippocampal injury over time following WBRT.
Impact: This study highlights the potential of multi-sequence MRI radiomics as a valuable tool for detecting and tracking hippocampal changes following WBRT, offering new insights for early intervention and improved management of cognitive decline in brain metastases patients.
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