Abstract #4359
Free Water mediates the association between glymphatic dysfunction and executive function performance
Xiaodan Liu1,2, Pauline Maillard3, Giuseppe Barisano4, Arvind Caprihan5, Steven Cen6, Xingfeng Shao1, Kay Jann1, John M. Ringman6, HanZhang Lu7, Konstantinos Arfanakis8,9, Charles S. DeCarli3, Brain T. Gold10, Sudha Seshadri11, Claudia L. Satizabal12, Alexa S. Beiser13, Mohamad Habes14, Joel H. Kramer15, Lara Stables15, Herpreet Singh16, Karl G. Helmer17,18,19, Steven M. Greenberg16, and Danny JJ. Wang1,6
1Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, United States, 2Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 3Department of Neurology, University of California, Davis, Sacramento, CA, United States, 4Department of Neurosurgery, Stanford University, Palo Alto, CA, United States, 5The Mind Research Network, Albuquerque, NM, United States, 6Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 7Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 8Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, 9Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, United States, 10Department of Neuroscience, University of Kentucky, Lexington, KY, United States, 11Population Health Sciences and Glenn Biggs Institute for Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States, 12Population Health Sciences and Glenn Biggs Institute for Neurodegenerative Diseases, satizabal@uthscsa.edu, San Antonio, TX, United States, 13Department of Biostatistics, School of Public Health, Boston University, Boston, MA, United States, 14Neuroimage Analytics Laboratory and Glenn Biggs Institute Neuroimaging Core, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States, 15Department of Neurology, University of California, San Francisco, San Francisco, CA, United States, 16Department of Neurology, Massachusetts General Hospital, Boston, MA, United States, 17Department of Radiology, Harvard Medical School, Boston, MA, United States, 18Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 19Department of Computer Science and AI Lab, Massachusetts Institute of Technology, Cambridge, MA, United States
Synopsis
Keywords: Dementia, DWI/DTI/DKI, free water (FW), diffusion tensor analysis along perivascular space (ALPS), executive function (EF), cerebral small vessel disease (cSVD), vascular cognitive impariment and dementia
Motivation: To explore biomarkers for cSVD related VCID
Goal(s): To examine the associations between the ALPS index and executive function performance and the potential mediation effect of free water on such association.
Approach: Four independent cohorts with racial and ethnic diversities were examined. Then the association between ALPS index and UDS3-EF scores and the mediation effect of free water were evaluated.
Results: ALPS index exhibited positive association with UDS3-EF scores and the free water mediated such association.
Impact: Our findings provide a strong clinical rationale for the use of the ALPS index as a marker of cSVD-related VCID.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
