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Abstract #4361

Cerebral iron load and cognitive impairment: the Atherosclerosis Risk in Communities (ARIC) Study

Lin Chen1,2, Di Zhao3, Eliseo Guallar4, Ziyang Xu1, Yi-Pei Liu1, Xinwei Zhou1, Bruce Wasserman5, Xu Li1,2, and Ye Qiao1
1The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, United States, 4Department of Epidemiology, New York University, NEW YORK, NY, United States, 5Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Other Neurodegeneration, biomarkers, dementia

Motivation: Quantitative susceptibility mapping (QSM) is used for direct mapping of brain tissue magnetic susceptibility, with iron being a major source in gray matter.

Goal(s): To examine the association between cerebral iron load, dementia, and cognitive function, independent of cardiovascular risk factors and small vessel disease.

Approach: We assessed the brain iron load in ARIC neurocognitive study. We used multivariate logistic regression to estimate risk of dementia and used generalized linear model to evaluate the associations of cognitive function scores and QSM levels.

Results: Higher cerebral iron load was associated with dementia, independent of APOE4 status, cardiovascular risk factors, and small vessel disease.

Impact: Higher cerebral iron load is associated with dementia, independent of APOE4 status, cardiovascular risk factors, and small vessel disease, suggesting its role in neurodegenerative disease pathogenesis, separate from vascular contributions

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