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Abstract #4366

Role of Inflammatory risk and myelin in executive function and episodic memory performance in a longitudinal lifespan sample of healthy adults

Chen Gonen1, Kristen M. Kennedy1, and Karen M. Rodrigue1
1Center for Vital Longevity, UT Dallas, Richardson, TX, United States

Synopsis

Keywords: Aging, Aging

Motivation: Explore the contribution of individual factors to structural brain changes, and the cognitive outcomes that are associated with such changes.

Goal(s): Study aimed to examine the effects of inflammatory risk factors on a myelin proxy, measured by the ratio of T1w and T2w images, as well as the interactions of these factors and myelin on cognition.

Approach: We utilized 3 neuroimaging techniques, genetic sequencing, and cognitive assessment to study the links between myelin, IL-1β, iron deposits, and cognition in general linear models.

Results: Myelin and iron interact to affect future executive function and memory performance across the lifespan.

Impact: We demonstrated that non-invasive and widely available imaging techniques can predict cognitive outcomes several years later, and thus might provide clinically relevant targets for mitigating cognitive aging.

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Keywords