Abstract #4369

Impacts of Cerebral Iron Accumulation on Cognitive Changes and Motor Dysfunction in Aging: A Quantitative Susceptibility Mapping (QSM) Study

Jonghyun Bae¹, Zhaoyuan Gong¹, Alex Guo¹, Noam Fox¹, Nathan Zhang¹, Angelique De Rouen¹, Hyeong-geol Shin^2,3, Xu Li^4,5, and Mustapha Bouhrara¹

¹National Institute on Aging, Baltimore, MD, United States, ²Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, ³F.M.Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, ⁴F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, ⁵Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Aging, Aging

Motivation: Iron accumulation is a prominent physiology of brain aging and various neurodegenerative disease. However, its implication in cognitive decline and motor dysfunction, main hallmarks of aging and age-related diseases, has received little attention.

Goal(s): To understand whether age-related iron accumulation in the brain is associated with changes in cognition and motor function.

Approach: We utilized quantitative susceptibility mapping (QSM) as a proxy for iron accumulation. QSM values were correlated with age and changes in cross-sectional and longitudinal cognitive performance and gait speed.

Results: Higher iron levels are associated with more rapid decline in multiple cognitive domains and impaired gait speed.

Impact: This study identifies iron accumulation as a key contributor to cognitive decline and motor dysfunction, calling for further investigations to inform the development of novel therapies and prevention strategies for neurodegenerative diseases and brain aging.

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