Keywords: Aging, Aging, Superager; DTI; memory, cerebral small vessel disease, white matter hyperintensity
Motivation: White matter integrity can contribute to cognitive resilience in superagers, but this has not been investigated.
Goal(s): Identify differences in cerebral small vessel disease between superagers and age-matched healthy older adults.
Approach: We conducted a regional-zonal analysis to map global and regional white matter hyperintensities (WMH) and utilized diffusion tensor imaging (DTI) to assess microstructural white matter integrity.
Results: Results showed that superagers have a lower WMH burden, particularly in the temporo-occipital lobes, which are critical for episodic memory, and exhibited higher fractional anisotropy (FA), suggesting that both macro- and microstructural white matter integrity can contribute to their preserved cognitive function.
Impact: A lower burden of cerebral small vessel disease (CSVD) at both macro- and microstructural levels may contribute to the superagers’ phenotype, emphasizing the importance of managing known CSVD risk factors, including hypertension, diabetes, hyperlipidemia, and smoking.
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