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Abstract #4372

Mapping Cerebral Small Vessel Disease in Superagers: Insights from White Matter Hiperintensity and DTI Analysis

Laiz Laura de Godoy1, Carole Sudre2, Adalberto Studart-Neto3, Bruno Pastorello4, Natália Cristina Moraes3, Mônica Sanches Yassuda3, Ricardo Nitrini3, Francesco Carletti5, Claudia da Costa Leite4, Sotirios Bisdas5, and Hans Rolf Jäger5
1Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States, 2Department of Computer Science, University College London, London, United Kingdom, 3Department of Neurology, University of Sao Paulo, Sao Paulo, Brazil, 4Department of Radiology and Oncology, University of Sao Paulo, Sao Paulo, Brazil, 5Lysholm Department of Neuroradiology, University College London, London, United Kingdom

Synopsis

Keywords: Aging, Aging, Superager; DTI; memory, cerebral small vessel disease, white matter hyperintensity

Motivation: White matter integrity can contribute to cognitive resilience in superagers, but this has not been investigated.

Goal(s): Identify differences in cerebral small vessel disease between superagers and age-matched healthy older adults.

Approach: We conducted a regional-zonal analysis to map global and regional white matter hyperintensities (WMH) and utilized diffusion tensor imaging (DTI) to assess microstructural white matter integrity.

Results: Results showed that superagers have a lower WMH burden, particularly in the temporo-occipital lobes, which are critical for episodic memory, and exhibited higher fractional anisotropy (FA), suggesting that both macro- and microstructural white matter integrity can contribute to their preserved cognitive function.

Impact: A lower burden of cerebral small vessel disease (CSVD) at both macro- and microstructural levels may contribute to the superagers’ phenotype, emphasizing the importance of managing known CSVD risk factors, including hypertension, diabetes, hyperlipidemia, and smoking.

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