Abstract #4375

Characterization of WMH penumbra and lesion progression using baseline and longitudinal WMH layer analysis with FLAIR and PCASL

Sang Hun Chung¹, Gen Li¹, Tianrui Zhao¹, Jianing Tang¹, Yining He¹, Elizabeth Joe², Helena Chui³, and Lirong Yan⁴

¹Northwestern University, Chicago, IL, United States, ²Clinical Neurology, University of Southern California, Los Angeles, CA, United States, ³Neurology, University of Southern California, Los Angeles, CA, United States, ⁴Radiology, Northwestern University, Chicago, IL, United States

Synopsis

Keywords: Aging, Aging, cerebral blood flow, ASL

Motivation: Characterization of the structural and functional changes along WMH lesion and penumbra could provide pivotal information about the mechanism of WMH development and progression.

Goal(s): To characterize WMH penumbra and WMH lesion progression using baseline and longitudinal WMH layer analysis using FLAIR and PCASL MRI

Approach: MRI FLAIR and PCASL were analyzed between baseline and follow-up acquisitions.

Results: FLAIR showed significance in all tested layers (p=0.0001 to 0.0005). CBF with PVC improved sensitivity to WMH progression in layers 4 and 5 (p=0.0055,0.0066). New WMH instances occurred predominantly by expansion from the baseline (94.92±5.80 % of new WMH)

Impact: Both FLAIR and pCASL CBF reveal the WMH progression. New WMH formation was shown to occur primarily by expansion from existing WMH. The WMH layer characterization may help elucidate the mechanics of the WMH progression.

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