Abstract #4380

In Vivo Human Brain MRSI at 10.5 T: Initial Insights

Lukas Hingerl¹, Bernhard Strasser¹, Simon Schmidt², Korbinian Eckstein³, Guglielmo Genovese², Edward J. Auerbach², Andrea Grant², Matt Waks², Andrew Wright⁴, Philipp Lazen^1,5,6, Alireza Sadeghi Tarakameh², Gilbert Hangel^1,5,6, Fabian Niess¹, Yigitcan Eryaman², Gregor Adriany², Gregory Metzger², Wolfgang Bogner^1,6, and Małgorzata Marjańska²

¹Department of Biomedical Imaging and Image-guided Therapy, HFMR, Medical University of Vienna, Vienna, Austria, ²Department of Radiology, University of Minnesota, Minneapolis, USA, Center for Magnetic Resonance Research, Minneapolis, MN, United States, ³The University of Queensland, School of Information Technology and Electrical Engineering, St Lucia, Australia, ⁴University of Texas Southwestern Medical Center, Dallas, USA, Advanced Imaging Research Center, Dallas, TX, United States, ⁵Department of Neurosurgery, Medical University of Vienna, Vienna, Austria, ⁶Christian Doppler Laboratory for MR Imaging Biomarkers, Vienna, Austria

Synopsis

Keywords: Data Acquisition, Spectroscopy, Ultra-High-Field

Motivation: Utilize the ultra-high field of 10.5 T for human in vivo brain MRSI investigations.

Goal(s): 3D mapping of an unprecedented high number of brain metabolites.

Approach: Employing a custom-built MR coil together with an optimized shimming tool and a robust FID-MRSI sequence with fast concentric ring readouts.

Results:

3D-FID-MRSI via concentric ring trajectory readouts at 10.5 T with nominal 2.75 mm isotropic resolution within 25 minutes.
Mapping of up to 13 brain metabolites plus macromolecules such as aspartate, GABA, glucose, glutamine and NAAG.
Dedicated parallel transmit and receive coil setup, with up to 80 coils, ensured high SNR and homogenous field distributions.

Impact: We have shown for the first time that ¹H-FID-MRSI of the human brain at 10.5 T allows for 3D mapping of up to 13 neurochemicals. This technology could offer a unique view into the metabolic intricacies of the human brain.

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