Abstract #4386
Bridging the gap: 150μm resolution whole brain ex-vivo imaging at 7T with RF shimming
Daniel Papp1,2,3, Matthias Weigel4,5,6,7, Mark Rekecki2,3, Hadrien van Loo3, Martin Cseh8, Adrian Szum2,3, Donggyun Park2,3, Kelvin Chow9, Tony Jimenez-Beristain10, Zsolt Geretovszky8, Laszlo Szekely11,12, Goncalo Castelo-Branco10, Cristina Granziera4,5,6, Tobias Granberg2,3, and Russell Ouellette2,3
1Siemens Healthineers, Stockholm, Sweden, 2Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden, 3Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden, 4Translational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel, Basel, Switzerland, 5Department of Neurology, University Hospital Basel, Basel, Switzerland, 6Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel and University of Basel, Basel, Switzerland, 7Division of Radiological Physics, Department of Radiology, University Hospital Basel, Basel, Switzerland, 8Center of Excellence for Interdisciplinary Research, Development and Innovation, 3D Center, University of Szeged, Szeged, Hungary, 9Cardiovascular MR R&D, Siemens Healthcare Ltd, Calgary, AB, Canada, 10Laboratory of Molecular Neurobiology, Research Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden, 11Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden, 12Laboratory of Clinical Pathology and Cytology, Karolinska University Hospital, Stockholm, Sweden
Synopsis
Keywords: High-Field MRI, High-Field MRI, ultra-high resolution, ex-vivo
Motivation: To demonstrate that ultra-high resolution whole brain MRI acquired at ultra-high field (7T) can be used to acquire mesoscale voxel sizes in ex-vivo samples, using commercially available hardware.
Goal(s): To evaluate the impact of RF-shimming methods on image quality in mesoscale MRI, and to acquire ex-vivo imaging with sufficient resolution and SNR to investigate mesoscale pathology.
Approach: At 150μm isotropic resolution, RF shimming approaches were compared for their SNR and CoV. Subsequently, high-SNR ex-vivo scanning was achieved by averaging and denoising, and used for neuroradiological reading.
Results: Ultra-high resolution MRI enabled the detection and delineation of fine lesions and mesoscale anatomical structures.
Impact: Using commercial hardware and overnight scan times, ultra-high resolution MRI at 150μm isotropic voxel size can be acquired with sufficient SNR and image quality to detect and differentiate mesoscale structures
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