Keywords: High-Field MRI, Spectroscopy
Motivation: Creatine and choline hold central roles in cellular energy metabolism. High-quality measurements of these metabolites in the heart provide key insights into cellular health and cardiac metabolism.
Goal(s): The aim of this work is to measure the percentage fraction of choline, creatine (CH3) and lipid methylene in the heart using water-suppression cycling (WSC) at 7T.
Approach: Hearts of six healthy volunteers were scanned using WSC and results were compared with standard water-suppressed (WS) acquisitions.
Results: Creatine and Choline were detected in four pairs of WSC and WS acquisitions. However, WSC provided better water alignment than WS, resulting in improved creatine and choline detection.
Impact: Frequency-aligned spectra from water-suppression cycled acquisitions enable the quantification of low-concentration metabolites in the heart at 7T.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords