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Abstract #4393

Water-cycled STEAM cardiac spectroscopy at 7T

Erin McConnell Montoya1,2, Ferenc Mozes1, Damian J Tyler1, and Ladislav Valkovic1,3
1OCMR, University of Oxford, Oxford, United Kingdom, 2Department of Physics, University of Oxford, Oxford, United Kingdom, 3Department of Imaging Methods, Slovak Academy of Sciences, Bratislava, Slovakia

Synopsis

Keywords: High-Field MRI, Spectroscopy

Motivation: Creatine and choline hold central roles in cellular energy metabolism. High-quality measurements of these metabolites in the heart provide key insights into cellular health and cardiac metabolism.

Goal(s): The aim of this work is to measure the percentage fraction of choline, creatine (CH3) and lipid methylene in the heart using water-suppression cycling (WSC) at 7T.

Approach: Hearts of six healthy volunteers were scanned using WSC and results were compared with standard water-suppressed (WS) acquisitions.

Results: Creatine and Choline were detected in four pairs of WSC and WS acquisitions. However, WSC provided better water alignment than WS, resulting in improved creatine and choline detection.

Impact: Frequency-aligned spectra from water-suppression cycled acquisitions enable the quantification of low-concentration metabolites in the heart at 7T.

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Keywords