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Abstract #4428

Innovative FE-DIC for Robust Motion and Intensity Correction in Dynamic CEST-MRI

Yijia Zheng1, Haizhou Liu1, Zhou Liu1, Yuxi Jin2, Zhihua Li2, Wei Cui3, Yin Wu2, Zhanli Hu2, and Dehong Luo1
1National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China, Shenzhen, China, 2Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, Shenzhen, China, 3MR Research China, GE Healthcare, Beijing, China, Beijing, China

Synopsis

Keywords: Motion Correction, Motion Correction

Motivation: Accurate motion correction of CEST-MRI is challenging due to the coupling effect between motion and intensity variations, which limits the precision of traditional intensity-based registration methods.

Goal(s): This study aimed to develop a framework that simultaneously corrects motion and intensity variations, enhancing registration accuracy while preserving intensity information.

Approach: We propose an innovative framework based on finite element global digital image correlation (FE-DIC), integrating mechanical regularization and intensity correction techniques to iteratively address the coupling of motion and intensity.

Results: Experiments on simulated human liver, clinical brain, and pig cardiac data show that proposed framework outperforms existing methods in reducing residual errors.

Impact: The proposed method enhances the reliability and precision of CEST-MRI, facilitating its applications in clinical and research settings.

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