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Abstract #4459

T1rho Relaxation Time as a Quantitative MRI Biomarker for Fibrosis Severity in Radiation-Induced Liver Disease: An Experimental Study in Rats

Yiqi Wang1, Yanting Jiang1, Junjie Wen2, Yi Zhang2, Yixiang J Wang3, and Feng Zhao1
1The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China, 2Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, Hangzhou, China, 3Department of Imaging and Interventional Radiology, Faculty of Medicine, The Chinese University of Hong Kong, Hongkong, China

Synopsis

Keywords: Relaxometry, Relaxometry

Motivation: HCC in China is common, with radiotherapy causing hard-to-diagnose RILD. MR T1rho imaging may help detect fibrosis early.

Goal(s): This study aimed to assess T1rho imaging performance in RILD and its ability to detect radiation-induced liver fibrosis in animals.

Approach: Thirty-three male Sprague-Dawley rats, including 9 controls and 24 irradiated with 25 Gy, underwent T1rho MR imaging at 2, 8, and 12 weeks post-radiation, with fibrosis assessed by NASH standards.

Results: The rats showed a time-dependent increase in liver fibrosis and T1rho values after radiation, confirmed by pathology and significant elevation at each time point compared to baseline.

Impact: T1rho MRI shows potential as a non-invasive method for detecting and monitoring liver fibrosis, enhancing early RILD diagnosis and guiding radiotherapy adjustments if validated in human studies.

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