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Abstract #4466

Development of a Double Echo-Shifted QUTE for quantification of T2* relaxation time at Ultra-High Field MRI.

Seonyeong Shin*1,2, Ana-Maria Oros-Peusquens*1, Seong Dae Yun1, and N. Jon Shah1,2,3,4,5
1Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany, 2RWTH Aachen University, Aachen, Germany, 3Institute of Neuroscience and Medicine 11, INM-11, JARA, Forschungszentrum Jülich, Jülich, Germany, 4JARA - BRAIN - Translational Medicine, Aachen, Germany, 5Department of Neurology, RWTH Aachen University, Aachen, Germany

Synopsis

Keywords: Relaxometry, Relaxometry, T2* mapping, echo-shifting technique, diffusivity, neurofluid

Motivation: T2* relaxation time is typically assessed using a multi-echo GRE sequence. However, the accurate quantification of slow-relaxing water pools, such as CSF, necessitates an extended scan time in comparison to that required for the quantification of brain tissue.

Goal(s): We present a new sequence (DES-QUTE), which is capable of acquiring three bunches of echoes corresponding to short, intermediate, and long TEs without a significant increase in the scan time.

Approach: The proposed sequence integrates QUTE with an improved echo-shifting technique.

Results: The DES-QUTE demonstrated accurate and precise T2* quantification at ultra-high field MRI, while providing a potential for simultaneous quantification of diffusion coefficients.

Impact: The proposed sequence offers an opportunity to sample different ranges of TE images and quantify both T2* and D information without a significant increase in scan time. This method is expected to make significant contributions to the study of neurofluids.

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