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Abstract #4468

Comparing the test-retest reproducibility of quantitative T1 and T2 mapping: DESPOT and 3D-QALAS

Gizeaddis Lamesgin Simegn1,2, Borjan Gagoski3,4, Yulu Song1,2, Douglas C. Dean III5,6,7, Kathleen E. Hupfeld1,2, Saipavitra Murali-Manohar1,2, Christopher W. Davies-Jenkins1,2, Dunja Simicic1,2, Jessica Wisnowski8, Vivek Yedavalli1, Aaron T. Gudmundson1,2, Helge J. Zöllner1,2, Georg Oeltzschner1,2, and Richard A. E. Edden1,2
1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Department of Radiology, Harvard Medical School, Boston, MA, United States, 4Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston, MD, United States, 5Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States, 6Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States, 7Waisman Center, University of Wisconsin-Madison, Madison, WI, United States, 8Department of Pediatrics, Division of Neurology, Children’s Hospital Los Angeles and the University of Southern California, Los Angeles, CA, United States

Synopsis

Keywords: Relaxometry, Analysis/Processing

Motivation: Measuring T1 and T2 relaxation times accurately is vital for understanding tissue properties. The choice of mapping method, including pulse sequence, parameters, hardware, and reconstruction, affects accuracy

Goal(s): This study evaluates and compares test-retest reproducibility of two MRI relaxometry techniques, DESPOT and QALAS, for T1 and T2 mapping in healthy volunteers.

Approach: Ten volunteers were scanned test-retest using DESPOT and QALAS. Reproducibility was analyzed using Bland-Altman plots, coefficient of variation, and intraclass correlation

Results: QALAS showed better reproducibility for T1 and was more time-efficient, while DESPOT showed slightly higher reproducibility for T2.

Impact: Establishing the reproducibility and accuracy of T1 and T2 mapping is crucial for their adoption in clinical practice and longitudinal studies, particularly for ‘hybrid’ methods, like DESPOT and QALAS, that map T1 and T2 from a set of mixed-contrast images.

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Abstract

Keywords