Abstract #4471

Influence of spin-locking direction on T1rho quantification: evaluation in phantoms with and without T1rho dispersion property

Jeehun Kim^1,2, Zhiyuan Zhang^1,2,3, Qi Peng⁴, and Xiaojuan Li^1,2,5

¹Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, OH, United States, ²Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States, ³Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ⁴Department of Radiology, Albert Einstein College of Medicine, Bronx, NY, United States, ⁵Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, Cleveland, OH, United States

Synopsis

Keywords: Relaxometry, Relaxometry, T1rho dispersion

Motivation: B0 and B1 inhomogeneities play a critical role in T1ρ preparation due to their strong impact on the fidelity of the resultant spin-locking. However, their influence on samples with T1ρ dispersion has not been fully investigated.

Goal(s): Evaluate the impact of B0 inhomogeneity on T1rho.

Approach: Phantoms without or with T1rho dispersion characteristic (agarose only, agarose+glucose, respectively) were scanned with T1rho preparation proposed by Chen, with a range of added B0 inhomogeneity.

Results: We observed different measured T1rho time with the size and polarity of B0 offset related to the on-resonance T1rho dispersion characteristic at the effective B1 magnitude.

Impact: A newly documented phenomenon on the T1rho preparation on different B0 inhomogeneity with magnetization locked to the effective B1 presents a new question on how to handle T1rho imaging with added inhomogeneity.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.