Abstract #4473

Transverse relaxation of metabolites from birth across the lifespan

Yulu Song^1,2, Abdelrahman Gad^1,2, Christopher W. Davies-Jenkins^1,2, Saipavitra Murali-Manohar^1,2, Helge J. Zöllner^1,2, Cristian Navarro^3,4, Mary Beth Nebel^3,4, Gizeaddis L. Simegn^1,2, Vivek Yedavalli¹, Georg Oeltzschner^1,2, and Richard A.E. Edden^1,2

¹Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Center for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, Baltimore, MD, United States, ⁴Department of Neurology, The Johns Hopkins School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Relaxometry, Spectroscopy, MRS, infants, relaxation times

Motivation: There is an urgent need to gather location-specific and age-resolved reference data to support MRS quantification of HBCD, the largest MRS study ever.

Goal(s): To measure metabolite transverse relaxation times T₂ of thalamus in a lifespan cohort.

Approach: Metabolite T₂s were measured in a cohort of 28 participants aged from 0 to 64 years old. PRESS-localized TE-series spectra in bilateral thalamus were linear combination modeled and T₂ estimated from exponential modeling of metabolite coefficients.

Results: There was a significant shortening of T₂ with age for the four major singlets, tNAA_2.0, tCr_3.0, tCr_3.9 and tCho.

Impact: Current practice in MRS quantification is to ignore well-known effects of brain-region and subject age on relaxation times. Location-specific and age-resolved T₂ reference values are a pre-requisite for accurate quantification of metabolite concentrations with MRS.

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