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Abstract #4476

Optimization of a [1-13C]pyruvic acid sample preparation for clinical hyperpolarization

Jean-Noel Hyacinthe1, Kylie Yeung2, Thanh Phong Lê3, Damian J. Tyler2, James T. Grist2, and Andrea Capozzi1,4
1LIFMET, EPFL, Lausanne, Switzerland, 2Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom, 3CIBM, EPFL, Lausanne, Switzerland, 4HYPERMAG, Technical University of Denmark, Lyngby, Denmark

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Non-Gas)

Motivation: Because of the nonrenewable out of equilibrium magnetization, hyperpolarized (HP) MRI is critically SNR-limited. In that context, more initial polarization should translate into superior diagnostic performances.

Goal(s): Optimizing the [1-13C]pyruvic acid preparation for a 5T clinical hyperpolarizer system.

Approach: Optimizing the sample preparation by measuring the electronic T1 (T1e) at actual clinical DNP conditions using in situ LOD-ESR measurements.

Results: Adding 0.5mM of DOTA-Gd chelate to the standard [1-13C]pyruvic acid clinical preparation led to an optimal T1e and consequent 1.5-fold increase in liquid state polarization.

Impact: Hyperpolarized-MRI diagnostic capability depends on the initial polarization of the contrast agent. Clinical polarizers are complex and expensive machines. We propose an easy to implement optimized sample preparation leading to a 50% SNR increase without any hardware modification.

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Keywords