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Abstract #4486

3D virtual biopsy of in vivo pH and metabolism using semi-LASER MRS of hyperpolarized 13C nuclei

Wolfgang Gottwald1, Luca Nagel1, Martin Grashei1, Sandra Sühnel1, Florian Matthias Gaksch1, Sebastian Bauer1, Nadine Setzer1, Geoffrey J Topping1, and Franz Schilling1,2,3
1Technical University of Munich, TUM School of Medicine and Health, Department of Nuclear Medicine, TUM University Hospital, Munich, Germany, 2Munich Institute of Biomedical Engineering, Technical University of Munich, Garching, Germany, 3German Cancer Consortium (DKTK), Partner Site Munich and German Cancer Research Center (DKFZ), Heidelberg, Germany

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Non-Gas)

Motivation: Hyperpolarized 13C magnetic resonance enables the detection of metabolism and pH using [1-13C]pyruvate or [1,5-13C2]Z-OMPD respectively. There is still a need for magnetization-efficient sequences with high spectral resolution and achieving large volume coverage.

Goal(s): To improve upon previously reported multi-voxel PRESS by implementing semi-LASER using adiabatic refocusing pulses, enabling localized MRS with 3D voxel placement.

Approach: A custom semi-LASER sequence was implemented and compared to PRESS in 1H phantoms and in animals using two hyperpolarized molecules.

Results: Semi-LASER enables dynamic localized MRS in mouse kidneys as well as pH measurements in more voxels and with a higher SNR than PRESS.

Impact: We show for the first time the use of adiabatic refocusing pulses for hyperpolarized 13C multi-voxel MRS to detect pH and metabolism, with high spectral resolution and short acquisition time, while maintaining high spatial customizability.

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