Keywords: Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Non-Gas)
Motivation: Hyperpolarized 13C magnetic resonance enables the detection of metabolism and pH using [1-13C]pyruvate or [1,5-13C2]Z-OMPD respectively. There is still a need for magnetization-efficient sequences with high spectral resolution and achieving large volume coverage.
Goal(s): To improve upon previously reported multi-voxel PRESS by implementing semi-LASER using adiabatic refocusing pulses, enabling localized MRS with 3D voxel placement.
Approach: A custom semi-LASER sequence was implemented and compared to PRESS in 1H phantoms and in animals using two hyperpolarized molecules.
Results: Semi-LASER enables dynamic localized MRS in mouse kidneys as well as pH measurements in more voxels and with a higher SNR than PRESS.
Impact: We show for the first time the use of adiabatic refocusing pulses for hyperpolarized 13C multi-voxel MRS to detect pH and metabolism, with high spectral resolution and short acquisition time, while maintaining high spatial customizability.
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