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Abstract #4488

In vivo imaging of 15N-Betaine: A long-lived, endogenous molecular contrast agent for hyperpolarized MRI

Ingeborg Sæten Skre1, Magnus Karlsson1, Rie Beck Olin1, and Mathilde Hauge Lerche1
1Health technology, Technical University of Denmark (DTU), Kongens Lyngby, Denmark

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), Contrast Agents, Nitrogen-15

Motivation: Hyperpolarized-MRI enables real-time molecular imaging, but short signal-lifetimes limit its use for observing delayed dynamics and uptake in vivo, motivating the development of longer-lived molecular contrast-agents.

Goal(s): We aim to demonstrate a long T1 and feasibility of in vivo MRI of 15N-Betaine and explore potential for multiple imaging sessions from a single dose.

Approach: 15N-Betaine was hyperpolarized by dDNP, and T1-values assessed. Dynamic 2D imaging of 15N-Betaine distribution in rodent kidneys was conducted at 3T.

Results: At 3T, T1 was >7 minutes in buffer and blood and 5.5 minutes in vivo. Imaging captured early rapid dynamics and later distribution from a single dose.

Impact: We introduce 15N-Betaine, a long-lived endogenous molecular contrast agent for hyperpolarized MRI, demonstrating feasibility for in vivo imaging. Its extended signal-lifetime supports prolonged acquisitions and enables flexible protocols with adaptable timing and resolution, offering a new tool for molecular imaging.

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