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Abstract #4494

Structural and microstructural characterization of corpus callosum integrity in paediatric-onset Huntington Disease

Maria Celeste Bonacci1,2, Maria Eugenia Caligiuri1,2, Ferdinando Squitieri3,4, and Umberto Sabatini1,2
1Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, Italy, Catanzaro, Italy, 2Neuroscience Research Center, Catanzaro, Italy, 3Centre for Neurological Rare Diseases (CMNR), Fondazione Lega Italiana Ricerca Huntington (LIRH), Rome, Italy, 4Huntington and Rare Diseases Unit, Fondazione IRCCS Casa Sollievo della Sofferenza (CSS) Hospital, San Giovanni Rotondo, Italy

Synopsis

Keywords: DWI/DTI/DKI, DWI/DTI/DKI, Corpus callosum, Huntington disease, paediatric-onset HD, adult-onset HD, fractional anisotropy, mean diffusivity

Motivation: Investigating the involvement of corpus callosum (CC) in paediatric-onset Huntington disease (POHD) using multimodal structural and diffusion MRI.

Goal(s): To compare macro- and microstructural integrity of CC in POHD compared to AOHD and to age-matched healthy controls (HC).

Approach: We analyzed differences in terms of volumes, thickness, fractional anisotropy (FA) and mean diffusivity (MD), extracted from the 5 subdivisions equally spaced along the postero-anterior direction of CC (posterior, middle-posterior, central, middle-anterior and anterior) in POHD, AOHD and HC.

Results: CC is substantially preserved in POHD compared to both HC and AOHD patients with similar disease severity.

Impact: This study provide first characterization of micro- and macrostructural alterations in POHD along the CC. Measures were compared between POHD and age- and sex-matched healthy-controls (PHC) as well as adult-onset HD(AOHD), to explore the differential involvements of these fibre tracts.

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Keywords