Abstract #4497

Correlation between multi-parameter MRI and Gleason score in prostate cancer using point-to-point irradiation analysis

Xiangpeng Zhao¹, Xinwei Ya², Li Kong², Xingrong Yang², Ke Meng², Yao Meng³, Chen Zhang⁴, Bing Wang², and Zixuan Kong²

¹Department of Radiology, the Second Affiliated Hospital of Dalian Medical University, Dalian, China, ²the Second Affiliated Hospital of Dalian Medical University, Dalian, China, ³MR Research Collaboration, Siemens Healthineers,, Beijing, China, ⁴MR Research Collaboration, Siemens Healthineers, Beijing, China

Synopsis

Keywords: DWI/DTI/DKI, Cancer

Motivation: Prostate cancer biopsy is invasive and may be influenced by sampling errors, causing abnormalities visible on MRI to be overlooked.

Goal(s): To propose a quantitative parameter for prostate cancer diagnosis.

Approach: Patients underwent 3T MRI scans. Prostate cancer diagnosis was confirmed by outlining regions of interest on T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and apparent diffusion coefficient (ADC) maps. Ratios for T2WI, DWI, and ADC values were calculated; Gleason score served as the reference standard.

Results: Clinically significant prostate cancer can be identified and differentiated by measuring T2WI ratios, DWI ratios, and ADC values specific to prostate cancer.

Impact: The proposed quantitative parameter, based on prostate cancer/obturator internus muscle signal intensity, enables noninvasive prostate cancer diagnosis and eliminates the need for biopsy.

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