Abstract #4504

Assessing Glymphatic Function Alterations in Gliomas: DTI-ALPS as a Potential Biomarker for Tumor Characteristics and Survival Analysis.

Qian Li¹, Rongde Zhong^2,3, Xuanle Li^1,4, Xiqian Zhang^1,5, Heng Wang⁶, Zhanli Hu^1,7,8, and Na Zhang^1,7,8

¹Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, ShenZhen, China, ²Department of Neurosurgery, Shenzhen Second People’s Hospital/The First Affiliated Hospital of Shenzhen University Health Science Center, ShenZhen, China, ³Guangdong Provincial Key Laboratory for Regional Immunity and Diseases, Department of Immunology, Shenzhen University School of Medicine, ShenZhen, China, ⁴Institute of Data Science, City University of Macau, Macau, China, ⁵University of Chinese Academy of Sciences, Beijing, China, ⁶Shenzhen Second People’s Hospital/The First Affiliated Hospital of Shenzhen University Health Science Center, ShenZhen, China, ⁷United Imaging Research Institute of Innovative Medical Equipment, ShenZhen, China, ⁸Key Laboratory of Biomedical Imaging Science and System, Chinese Academy of Sciences, ShenZhen, China

Synopsis

Keywords: DWI/DTI/DKI, Brain, Glymphatic Function

Motivation: Researching the glymphatic system's role in brain fluid balance is essential for understanding brain tumor-induced homeostasis disruption and advancing treatment development.

Goal(s): To evaluate the glymphatic function alterations associated with glioma by calculating DTI-ALPS and exploring its prognostic value.

Approach: This study proposes a method for calculating DTI-ALPS in the contralateral cerebral hemisphere and utilizes statistical and machine learning techniques to evaluate glymphatic function in glioma.

Results: Patients with highly invasive tumors (such as glioblastoma, IDH-wildtype, 1p19q-intact, complex edema shape and tumor texture) consistently exhibited reduced glymphatic function. DTI-ALPS combined with radiomic features improved survival prediction.

Impact: This study emphasizes a significant connection between glymphatic function changes, tumor characteristics, and survival prognosis, providing a radiological basis for further neuro-oncological research on the glymphatic system.

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