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Abstract #4506

Gray matter Abnormalities in Systemic Lupus Erythematosus Patients without Neuropsychiatric Symptoms: A Multi-shell Diffusion Imaging Study

Wenjun Hu1, Ziru Qiu2,3, Fuqiang Wu1, Xinyuan Zhang2,3, and Xiangliang Tan1
1Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, Chin, Guangzhou, China, 2School of Biomedical Engineering, Southern Medical University, Guangzhou, China, Guangzhou, China, 3Guangdong Provincial Key Laboratory of Medical Image Processing and Guangdong Province Engineering Laboratory for Medical Imaging and Diagnostic Technology, Southern Medical University, Guangzhou, China, Guangzhou, China

Synopsis

Keywords: DWI/DTI/DKI, DWI/DTI/DKI

Motivation: Systemic lupus erythematosus (SLE) induces brain structural alterations, even in the absence of neuropsychiatric symptoms.

Goal(s): Investigate cortical microstructure alterations in SLE patients without neuropsychiatric manifestations, identify most damaged regions, and assess diagnostic efficacy of diffusion models.

Approach: Gray matter-based spatial statistics (GBSS) on DKI and NODDI data were conducted for microstructure analysis. Overlaps of significantly different regions from surface-based morphometry and GBSS were calculated to identify critical areas. Logistic regression was applied to compare diagnostic efficacy of models.

Results: SLE patients exhibited increased MD, MK, NDI and ODI; temporal and frontal lobes most affected. Combined diffusion model demonstrated optimal diagnostic efficacy.

Impact: This study provides a comprehensive understanding of gray matter changes and pinpoints the most affected regions in SLE. The combination of DKI and NODDI models presents optimal diagnostic efficacy.

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