Keywords: DWI/DTI/DKI, DWI/DTI/DKI
Motivation: Systemic lupus erythematosus (SLE) induces brain structural alterations, even in the absence of neuropsychiatric symptoms.
Goal(s): Investigate cortical microstructure alterations in SLE patients without neuropsychiatric manifestations, identify most damaged regions, and assess diagnostic efficacy of diffusion models.
Approach: Gray matter-based spatial statistics (GBSS) on DKI and NODDI data were conducted for microstructure analysis. Overlaps of significantly different regions from surface-based morphometry and GBSS were calculated to identify critical areas. Logistic regression was applied to compare diagnostic efficacy of models.
Results: SLE patients exhibited increased MD, MK, NDI and ODI; temporal and frontal lobes most affected. Combined diffusion model demonstrated optimal diagnostic efficacy.
Impact: This study provides a comprehensive understanding of gray matter changes and pinpoints the most affected regions in SLE. The combination of DKI and NODDI models presents optimal diagnostic efficacy.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords